.ALPHA.-O-LINKED GLYCOCONJUGATES, METHODS OF PREPARATION AND USES THEREOF
摘要
The present invention provides novel .alpha.-O-linked glycoconjugates such as .alpha.-O-linked glycopeptides, as well as convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces. The present invention further provides compositions and methods of treating cancer using the .alpha.-O-linked glycoconjugates.
申请公布号
CA2286798(A1)
申请公布日期
1998.10.22
申请号
CA19982286798
申请日期
1998.03.25
申请人
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
发明人
SAMES, DALIBOR;WILLIAMS, LAWRENCE;LIVINGSTON, PHILIP O.;DANISHEFSKY, SAMUEL J.;KUDUK, SCOTT;SCHWARZ, JACOB B.;HINTERMANN, SAMUEL;CHEN, XIAO-TAO;GLUNZ, PETER;RAGUPATHI, GOVINDASWAMI