Mur d inhibiting compounds, compositions containing such compounds and methods of use

摘要

The present invention addresses compounds which inhibit Mur D. The compounds are represented by structural formula 1: wherein: X represents OH, OC1-6 alkyl, O-aryl, O-Har, uridinyl, 5-iodouridinyl or O-Y+, wherein Y+ represents a charge balancing group; R1 and R2 independently represent H or C1-6 alkyl, or R1 and R2 taken together represent C1-6 alkylene unsubstituted or substituted with from 1-2 aryl or Har groups; W represents H, aryl, C1-6 alkyl or a charge balancing group; each M independently represents a member selected from the group consisting of: H, a charge balancing group and a protecting group. Salts and hydrates thereof are included. Also included are pharmaceutical compositions and methods of treatment.