ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF ACTIVATING PROTEIN 1
摘要
Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of Activating Protein 1 (AP-1) expression are provided. In accordance with various embodiments of the present invention, oligonucleotides are provided which are specifically hybridizable with c-fos or c-jun, the genes encoding c-Fos or c-Jun, respectively. In a preferred embodiment, a method of modulating the metastasis of malignant tumors via modulation of one or more of the AP-1 subunits is provided; this method can be effected using the oligonucleotides of the invention or any other agent which modulates AP-1 or AP-1-mediated transcription.
申请公布号
WO9846272(A1)
申请公布日期
1998.10.22
申请号
WO1998US07386
申请日期
1998.04.14
申请人
ISIS PHARMACEUTICALS, INC.;DEAN, NICHOLAS, M.;MCKAY, ROBERT;MIRAGLIA, LOREN;BAKER, BRENDA
发明人
DEAN, NICHOLAS, M.;MCKAY, ROBERT;MIRAGLIA, LOREN;BAKER, BRENDA