| 摘要 |
Methods of immunizing a vertebrate, by inoculating the vertebrate with a nucleic acid vaccine in conjunction with a saponin adjuvant, such as the adjuvant QS-21, are disclosed. The saponin adjuvant can be administered within approximately 10 days, preferably within approximately 5 days, and more preferably within approximately 2 days, before the nucleic acid vaccine; contemporaneously with the vaccine; or within approximately 10 days, preferably within approximately 7 days, and more preferably within approximately 1 day, after the nucleic acid vaccine. Compositions comprising a nucleic acid vaccine and a saponin adjuvant are also disclosed.
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