发明名称 |
TREATMENT OF CANCER BY THE ADMINISTRATION OF FAS LIGAND EXPRESSING NON-TUMORIGENIC CELLS |
摘要 |
The present invention provides a method of treating solid tumors wherein the cells of the tumor express the Fas receptor. The method comprises administering to the tumor cells non-tumorigenic cells which express the Fas ligand. The non-tumorigenic cells can be myoblasts which may be a naturally Fas deficient strain of primary skeletal myoblasts transduced with the gene encoding the Fas ligand. These non-tumorigenic cells can be administered to the tumor cells of interest either in vivo at a tumor site or a site from which a tumor has been removed or in vitro. The tumor cells can be rhabdomyosarcoma-derived tumor cells.
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申请公布号 |
WO9846242(A1) |
申请公布日期 |
1998.10.22 |
申请号 |
WO1998US07235 |
申请日期 |
1998.04.10 |
申请人 |
STANFORD UNIVERSITY |
发明人 |
BLAU, HELEN, M.;HOFMANN, ANDREAS |
分类号 |
A61K39/00;A61K48/00;C12N5/077;G01N33/566;(IPC1-7):A61K35/34;C12N5/10;A61K45/00;G01N33/50 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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