| 发明名称 |
Brefeldin A derivatives and their utility in the treatment of cancer |
| 摘要 |
Provided are brefeldin A derivatives of the formula: <IMAGE> (II) wherein one of R1 and R2 is H and the other of R1 and R2 is a substituent group having 1 to 12 carbon atoms containing a basic nitrogen atom or a quaternary ammonium group, or a salt thereof. These derivatives exhibit good antitumor activity, and are administrable to human patients without the problems associated with brefeldin A.
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| 申请公布号 |
US5824674(A) |
申请公布日期 |
1998.10.20 |
| 申请号 |
US19970974902 |
申请日期 |
1997.11.20 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;STARKS ASSOCIATES |
发明人 |
MALSPEIS, LOUIS;VISHNUVAJJALA, B. RAO;SUPKO, JEFFREY G.;KANE, JR., CHARLES THEODORE |
| 分类号 |
A61K31/365;A61P35/02;C07D313/00;(IPC1-7):A61K31/365;A61K31/55 |
主分类号 |
A61K31/365 |
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