Quinoline compound extracted from scolopendra subspinipes, and derivatives thereof

摘要

The jineol extracted from scolopendra subspinipes is represented as the following formula (I): <IMAGE> (I) The jineol is obtained from scolopendra subspinipes by extracting scolopendra subspinipes with a solvent, separating an activating portion from the extracted liquid with an organic solvent, and purifying an anticancerous activating portion from the activating portion by chromatography. The jineol derivatives prepared from the jineol extracted scolopendra subspinipes are represented as the following formula (II): <IMAGE> (II) wherein each R1 and R2, independently of each other, is a hydrogen; a lower alkyl group of C1 to C6; a cycloalkyl group of C5 to C7 having a substituting group; an alkyl group of C1 to C4 having a phenyl group with one to three substituting groups; a lower alkyl group of C1 to C6 having a hydroxy, an alkoxy having C1 to C5, or an aryloxy; a lower acyl group of C1 to C7 having a hydroxy, an alkoxy having C1 to C5, or an aryloxy; a cycloalkylcarbonyl group of C5 to C7 with one to three substituting groups; or an acyl group of C1 to C4 having a phenyl group with one to three substituting groups.