Therapeutic powder formulation for pulmonary administration, containing crystalline insulin

摘要

A therapeutic powder formulation suitable for pulmonary administration comprising particles composed of human insulin or any analogue or derivative thereof and an enhancer which enhances the absorption of insulin in the lower respiratory tract is disclosed. The powder formulation has a better stability profile than powders of essentially the same composition prepared by spray drying, freeze-drying, vacuum drying and open drying.