Expression of human interleukin-1 beta in a transgenic animal

摘要

PCT No. PCT/US94/08111 Sec. 371 Date Apr. 22, 1996 Sec. 102(e) Date Apr. 22, 1996 PCT Filed Jul. 19, 1994 PCT Pub. No. WO95/03402 PCT Pub. Date Feb. 2, 1995A transgenic mouse has been prepared that expresses a human interluekin-1 beta transgene. Expression of the transgene is mediated by a mouse metallothionein promoter. As a result of the expression of this transgene, the mouse has inflammation of its kidney and liver. The claimed animals are useful as screening tools for agents that are potentially useful for treating inflammation.