A pharmaceutical preparation for oral insulin delivery comprising a stable, hydrophobic emulsion comprising continuous phase of a hydrophobic material selected from the group consisting of a long chain carboxylic acid or ester or alcohol thereof dispersed in an aqueous phase or (ii) having a hydrophilic discontinuous phase dispersed in a hydrophobic phase of a long chain carboxylic acid or alcohol thereof. The emulsion with insulin is incorporated into a pharmaceutical carrier suitable for oral delivery.
申请公布号
US5824638(A)
申请公布日期
1998.10.20
申请号
US19950446399
申请日期
1995.05.22
申请人
SHIRE LABORATORIES, INC.
发明人
BURNSIDE, BETH A.;MATTES, CAROL E.;MCGUINNESS, CHARLOTTE M.;RUDNIC, EDWARD M.;BELENDIUK, DECEASED, GEORGE W.