Phospphine-phosinite compound and process for preparing 4-[(R)-1'-formylethyl]-azetidin-2-one derivatives using the same

摘要

A phosphine-phosphinite compound represented by formula (I): <IMAGE> (I) wherein R1 and R2, which may be the same or different, each represent a substituted or unsubstituted phenyl group or a substituted or unsubstituted naphthyl group, and a process for preparing a 4-[(R)-1'-formylethyl]azetidin-2-one derivative using the compound (I). The compound (I), either in combination, or as a complex, with a transition metal compound, is useful as a catalyst for asymmetric hydroformylation and makes it possible to easily synthesize an important intermediate for carbapenem antibiotics or a precursor thereof at high regioselectivity and diastereo-selectivity.