| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound good in stability against a dehydropeptidase-I, exhibiting an excellent antibacterial activity, high in recovery rate in urine and useful as an antibacterial agent for treating or preventing a bacterial infectious disease. SOLUTION: This tricyclic heterocyclic compound is a compound of formula I A is a group of formula II [(k) is 0, 1; (m) is 0, 1, 2; R<2> is H, a 1-4C alkyl, etc.; R<3> is H, oxo, sulfamoylaminomethyl, etc.), formula III [(q) is 0, 1, 2; R<9> is phenyl which may have 1-3 substituting groups, etc.], etc.} or a pharmacologically permissible salt or a derivative thereof, and e.g. a compound of formula IV is cited. In order to obtain a compound of formula I, e.g. a method of starting from the sulfonylation of a compound of formula V (R<14> is a protecting group for hydroxyl group), a substitution reaction, a ring closure reaction, and a deprotecting reaction, is cited. |
