| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new compound capable of reducing the concentration of an (ultra) low density lipoprotein cholesterol in plasma or serum and useful for treating and preventing hyperlipemia such as atherosclerosis. SOLUTION: This compound is represented by formula I R<1> and R<2> are each a straight-chain 1-6C alkyl; R<3> is H or OR<11> [R<11> is H or a (substituted) 1-6C alkyl]; R<4> is pyridyl or a (substituted) phenyl; R<5> , R<6> and R<8> are each H, a halogen, cyano, etc.; R<7> is represented by formula II (R<16> is COOH, CH2 OH, etc.), etc.; X is NH or O; R<9> and R<10> are each H or 1-6C alkyl}. The objective compound is prepared by acylating or alkylating a compound represented by formula III at the group X-H according to the standard method or glycosylating or glucuronidating the compound represented by formula III at the group X-H and then eliminating the protecting group, especially hydroxyl group and amino functional group. |
