| 摘要 |
<p>FIELD: chemical industry. SUBSTANCE: present invention concerns perhydroisoindole derivatives of general formula (I) wherein R symbols are identical and are phenyl radicals substituted optionally by halogen or methyl in position 2 or 3, and <EMI ID=0.147 HE=3 WI=3 TI=CHI> is phenyl substituted optionally in position 2 by alkyl or alkoxy containing 1 or 2 carbon atoms, <EMI ID=0.148 HE=3 WI=3 TI=CHI> is fluorine or hydroxy, and <EMI ID=0.149 HE=3 WI=6 TI=CHI> is hydrogen or <EMI ID=0.150 HE=3 WI=3 TI=CHI> and <EMI ID=0.151 HE=3 WI=6 TI=CHI> are hydroxy, or <EMI ID=0.152 HE=3 WI=3 TI=CHI> forms bond with <EMI ID=0.153 HE=3 WI=6 TI=CHI>, and R is hydrogen or protecting radical, and also salts thereof when they are present, and preparation thereof. Intermediate synthesis compounds for preparation of derivatives having antagonistic activity with respect to compound P. EFFECT: improved properties of the title compounds. 8 cl, 42 ex, 1 tbln</p> |
