| 摘要 |
PCT No. PCT/JP95/00699 Sec. 371 Date Oct. 1, 1996 Sec. 102(e) Date Oct. 1, 1996 PCT Filed Apr. 10, 1995 PCT Pub. No. WO95/27697 PCT Pub. Date Oct. 19, 1995Compounds of the general formula: <IMAGE> (I) wherein R1 represents a C1-10 alkyl group which may be substituted by one or more hydroxyl groups, R2 represents a hydrogen atom or a hydroxyl group, and R3 represents a hydrogen atom or a hydroxyl group; their intermediates; as well as synthesis processes of these compounds and intermediates are disclosed. The compounds of this invention, vitamin D derivatives substituted by sulfur atoms at the 22-position have a strong inhibitory effect against proliferation of keratinocytes.
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