| 摘要 |
<p>A process of synthesizing a compound of formula 1: wherein P and P' independently represent H or a protecting group, R1 represents H or C1-4alkyl, and Hal represents a halogen, comprising: reacting a compound of formula 2: wherein P, P', and R1 are defined above, with R2OH, wherein R2 is C1-4 alkyl, C5-10 aryl or C5-10 heteroaryl in the presence of an acid catalyst or carbodiimide reagent to produce a compound of formula 3: wherein P, P', and R1 are defined above; and reacting a compound of formula 3 in the presence of a base and a haloalkylating agent to produce a compound of formula I.</p> |
