发明名称 |
NITRATION OF AROMATIC COMPOUNDS |
摘要 |
<p>A method of nitrating electron-deficient carbocyclic or heterocyclic aromatic compounds such as pyridines, diazines and triazines and benzenoid aromatics having electron-withdrawing substituents involves first reacting the aromatic species with a sulphilimine species or with the corresponding N-alkali metal salt thereof to generate an N-(hetero)aryl-S,S-dialkyl, diaryl or alkylarysulphilimine derivative. This intermediate may then be readily oxidised under relatively mild conditions using a peroxycarboxylic acid such as m-chloroperbenzoic acid, peracetic or peroxytrifluoroacetic acid. Good yields of nitrated products are obtained including some previously unprepared. The novel N-alkali(alkylaryl)sulphilimine reagents are prepared by reacting an alkali metal hydride, an alkali metal hydrogenous base or an alkyl lithium with the corresponding sulphilimine. Preferred salts are the N-lithio types and the preferred sulphilimine is diphenylsulphilimine. Where the salt is used reaction should be in an aprotic solvent but if the sulphilimine per se is the reagent a polar solvent is used.</p> |
申请公布号 |
CZ9801867(A3) |
申请公布日期 |
1998.10.14 |
申请号 |
CZ19980001867 |
申请日期 |
1996.12.09 |
申请人 |
THE SECRETARY OF STATE FOR DEFENCE |
发明人 |
MILLAR ROSS WOOD;CLARIDGE ROBERT PETER;SANDALL JOHN PAUL BENET;THOMPSON CLAIRE |
分类号 |
C07C201/10;C07C205/12;C07C381/10;C07D213/61;C07D213/76;C07D239/42;C07D241/16;C07D241/20;C07D251/44;C07D251/46;(IPC1-7):C07D213/76;C07D251/42;C07D239/30;C07B43/02;C07D251/52 |
主分类号 |
C07C201/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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