| 摘要 |
<p>The present invention relates to novel amino acid derivatives having an N, N-dialkylaminophenyl group represented by the general formula ÄIÜ. <CHEM> wherein R<1> represents a hydrogen atom, a lower alkyl group, a phenyl-lower alkyl group, a lower alkanoyl group or a benzoyl group, and each phenyl ring in the phenyl-lower alkyl group and the benzoyl group can be substituted by a halogen atom, a lower alkyl group or a lower alkoxy group; R<2> represents a carboxyl group which can be converted into an ester, an amide or a hydroxamic acid; R<3> represents a lower alkyl group; R<4> represents a lower alkyl group; A<1> represents a lower alkylene group which can be substituted by a phenyl group, and the phenyl group can be substituted by a halogen atom, a lower alkyl group or a lower alkoxy group; A<2> represents a lower alkylene group; A<3> represents a lower alkylene group; and "Z" represents a sulfur atom or an oxygen atom. The compounds have inhibitory effects on LTA4 hydrolase and are useful as medicines, in particular, therapeutic agents for inflammatory diseases such as rheumatic diseases, psoriasis, inflammatory intestinal diseases, gout and cystic fibrosis, in which LTB4 is concerned.</p> |
