| 摘要 |
PCT No. PCT/GB95/00279 Sec. 371 Date Apr. 10, 1996 Sec. 102(e) Date Apr. 10, 1996 PCT Filed Feb. 10, 1995 PCT Pub. No. WO95/21823 PCT Pub. Date Aug. 17, 1995This invention concerns a compounds of generic formula: <IMAGE> (I) or a pharmaceutically acceptable salt thereof, where the dotted lines represent optional bonds with the nitrogen ring optional bonds being between one adjacent pair on ring atoms, R3 is an optionally substituted C6-C10 aryl or heteroaryl group; said aryl or heteroaryl radicals being optionally substituted by one or more substituents the same or different, R4 represents hydrogen, or a group of formula -CRaRbRc where Ra, Rb and Rc are independently selected from hydrogen, C1-C6 alkyl, optionally substituted C6-C10 aryl, optionally substituted heteroaryl, C1-C6 alkyl substituted by optionally substituted C6-C10 aryl or heteroaryl, R' represents one or more optional substituents the same or different, selected from one or more of the following: halogen, C1-C6 alkyl, C2-C7 alkoxycarbonyl, C1-C6 hydroxyalkyl, CN, aminocarbonyl, C2-C7 alkanoyloxy(C1-C6)alkyl, carboxy, C2-C7 alkanoxyamino, optionally substituted C6-C10 or heteroaryl or an optionally substituted (C6-C10 aryl)alkyl or a heteroaryl alkyl radical; said aryl or heteroaryl radicals being optionally substituted by one or more substituents the same or different, and R'' represents one or more optional mono- or di- valent substituents in the 5, 7 or 8 positions the same or different: monovalent substituents being selected from the following: C1-C6 alkyl, C2-C7 alkanoyloxy, hydroxy, amino, C2-C7 alkanoylamino, C1-C6alkylamino, C1-C6 hydroxalkyl, R'' can also represent hydroxy in the 6 position (when the optional bond is absent); the di-valent substituents being selected from oxo (i.e=O) and methylene (i.e =CH2). which compounds have pharmaceutical uses conferred by their ability to block voltage gated potassium channels.
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