发明名称 |
Combinatorial dihydrobenzopyran library |
摘要 |
Combinatorial libraries are disclosed which are represented by Formula I:(T'-L)q-+E,crc S+EE -C(O)-L'-II'Iwherein: +E,crc S+EE is a solid support; T'-L- is an identifier residue; and -L'-II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of the formula: <IMAGE> II which interact (i.e., as agonists or antagonists) with alpha adrenergic receptors, dopamine receptors, sigma -opiate receptors, and K+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatment of ocular diseases such as glaucoma.
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申请公布号 |
US5821130(A) |
申请公布日期 |
1998.10.13 |
申请号 |
US19950552698 |
申请日期 |
1995.11.03 |
申请人 |
PHARMACOPEIA, INC. |
发明人 |
BALDWIN, JOHN J.;READER, JOHN C.;DILLARD, LAWRENCE W.;LI, GE;ZENG, WENGUANG |
分类号 |
C07B61/00;C07C205/59;C07D311/08;C07D311/22;C07D311/96;C07D491/10;C07D493/10;C07D495/10;C12Q1/00;G01N33/573;(IPC1-7):G01N33/543;C07C233/11 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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