Targeted cytolysis of cancer cells

摘要

Chimeric proteins and DNA encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to A33 in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. Binding of A33 to the extracellular domain results in transduction of a signal and activation of a singaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signaling pathway. The chimeric DNA may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.