| 摘要 |
FIELD: organic chemistry and chemical technology. SUBSTANCE: invention relates to compounds of the formula (I): <EMI ID=0.101 HE=27 WI=63 TI=CHI> where A is carbon-nitrogen bond or unbranched C<SB>1</SB>-C<SB>4</SB>-alkylene group; X is nitromethylene group, cyanomethylene group substituted with cyano-group, aminocarbonyl or C<SB>1</SB>-C<SB>3</SB>-alkoxycarbonyl or a group of the formula =N-R<SB>7</SB> where R<SB>7</SB> is cyano-group, C<SB>1</SB>-C<SB>3</SB>-alkanesulfonyl, phenylsulfonyl, aminosulfonyl, aminocarbonyl or phenylcarbonyl; Y is C<SB>1</SB>-C<SB>3</SB>-alkoxy-group, phenoxy- or group R<SB>8</SB>NR<SB>9</SB> where R<SB>8</SB> is hydrogen, C<SB>1</SB>-C<SB>8</SB>-alkyl that at 2, 3 or 4 position can be substituted with hydroxy-group, C<SB>1</SB>-C<SB>3</SB>-dialkylamino-group, substituted C<SB>1</SB>-C<SB>4</SB>-alkyl group, that can be substituted additionally with hydroxyl-group at 2, 3 or 4 position and others; R<SB>1</SB> is hydrogen, C<SB>1</SB>-C<SB>3</SB>-alkyl; R<SB>9</SB> is hydrogen, C<SB>1</SB>-C<SB>3</SB>-alkyl; R<SB>2</SB> and R<SB>3</SB> are hydrogen or form together carbon-carbon bond; Pyr is pyridyl group; R<SB>4</SB> is tetrazolyl, aminocarbonyl, C<SB>1</SB>-C<SB>4</SB>-dialkylaminocarbonyl and others; R<SB>8</SB> is hydrogen, trifluoromethyl, C<SB>1</SB>-C<SB>3</SB>-alkyl, C<SB>1</SB>-C<SB>3</SB>-alkyl; n = 2, 3, 4, 5. The synthesized derivatives of pyridine, their enantiomers, cis- or trans-isomers and their salts can be used in pharmaceutical composition showing inhibition of platelets aggregation and thromboxane synthesis. EFFECT: improved method of synthesis, enhanced effectiveness of pharmaceutical composition. 5 cl, 1 tbl, 27 ex, |
