Recombinant DNA molecules comprising a regulatory element that activates gene expression in response to DNA damage operatively linked to a DNA sequence that encodes a light emitting reporter protein, recombinant vectors containing such DNA molecules and cells containing the DNA molecules or recombinant vectors. A method of detecting for the presence of an agent that causes or potentiates DNA damage is also disclosed which involves subjecting the above-described cells to a putative DNA damaging agent and monitoring the expression of the light emitting reporter protein from the cells.
申请公布号
WO9844149(A1)
申请公布日期
1998.10.08
申请号
WO1998GB00786
申请日期
1998.03.27
申请人
THE UNIVERSITY OF MANCHESTER INSTITUTE OF SCIENCE & TECHNOLOGY;WALMSLEY, RICHARD, MAURICE;HEYER, WOLF, DIETRICH