PROCESS FOR THE PREPARATION OF N-(3-HYDROXY-SUCCINYL)-AMINO ACID DERIVATIVES

摘要

Processes for preparing compounds of the formula (I) are described: P<1>OOC-CH(OH)-CHR<1>-CONH-Z wherein P<1> is hydrogen or a protecting group, Z is a group -CHR<2>COOP<2> or -CHR<2>CONR<3>R<4> wherein P<2> is hydrogen or a protecting group and R<1>-R<4> are values known in the TNF-inhibitor art. The compounds of the formula (I) are useful in inhibiting TNF and one or more matrix metalloproteinase enzymes. One intermediate in a process of the invention is formula (II).