发明名称 |
MODIFIED ADENOVIRAL FIBER AND TARGET ADENOVIRUSES |
摘要 |
The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said adenovirus. The invention further relates to a DNA fragment, and expression vector, and a cell line expressing said fiber, and also concerns an adenovirus, the process for producing this type of adenovirus, and a infectable host cell, as well as their therapeutic application and a corresponding pharmaceutical composition.
|
申请公布号 |
WO9844121(A1) |
申请公布日期 |
1998.10.08 |
申请号 |
WO1998FR00668 |
申请日期 |
1998.04.02 |
申请人 |
TRANSGENE S.A.;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);LEGRAND, VALERIE;MEHTALI, MAJID;BOULANGER, PIERRE |
发明人 |
LEGRAND, VALERIE;MEHTALI, MAJID;BOULANGER, PIERRE |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K38/27;A61K38/28;A61K38/43;A61K38/55;A61K39/395;A61K48/00;C07K14/075;C12N5/10;C12N7/00;C12N15/34;C12N15/861;(IPC1-7):C12N15/34;C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|