Neue Thiodepsipeptide zur Bekämpfung von Endoparasiten und ein einfaches Verfahren zu ihrer Herstellung

摘要

The invention relates to cyclic thiodepsipeptides, especially 18 to 24-link cyclothiodepsipeptides, cyclic thiodepsipeptides and their salts. These cyclic thiodepsipeptides are of general formula (I), wherein R<1>, R<4>, R<7> and R<10> represent, independently of each other, hydrogen, straight-chain or branched C1-4alkyl, R<2>, R<5>, R<8> and R<11> represent, independently of each other, hydrogen, straight-chain or branched C1-8 alkyl, C1-8 alkenyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-2 alkyl, aryl-C1-2 alkyl, heteroaryl-C1-2 alkyl, aryl or heteroaryl which are optionally substituted, R<9> and R<10>, together with the atoms to which they are bonded, represent a 5 or 6-link ring which is optionally substituted, R<10> and R<11>, together with the atoms to which they are bonded, represent a 5 or 6-link ring which can be optionally interrupted by oxygen, sulfur, sulfoxy or sulfonyl and is optionally substituted, R<3> and R<9> represent, independently of each other, hydrogen, C1-8 alkyl or aryl-C1-2 alkyl, C3-6-cycloalkyl-C1-2 alkyl, R<6> and R<12> represent, independently of each other, hydrogen, straight-chain or branched C1-8 alkyl, C1-8 alkenyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-2 alkyl, aryl-C1-2 alkyl, heteroalkyl-C1-2 alkyl, aryl or heteroaryl which are optionally substituted, and X<1>, X<2>, X<3> and X<4> represent oxygen or sulfur independently of each other, at least one of the radicals X<1>, X<2>, X<3> and X<4> being required to represent sulfur. The invention also relates to the optical isomers and racemates of the inventive thiodepsipeptides.