| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject derivative having high activity and safety and useful as a therapeutic agent for diseases by which calcium metabolism, etc., is abnormalized by reacting a specific exomethylene derivative with a specific ene-yne derivative. SOLUTION: This derivative is represented by formula I (A and B are each H or A and B together forms C-C bond; star symbol represents that configuration of the carbon is either one of R-configuration and S-configuration), e.g. 1α, 24(R)dihydroxy 25-nitrovitamine B3 . Furthermore, the derivative is obtained by reacting an exomethylene derivative represented by formula II [R<1> is H, a 2-8C acyl or a tri(1-6C hydrocarbon)-substituted silyl, etc.; X is bromine or iodine] with an ene-yne derivative represented by formula II [R<2> and R<3> are each H or a tri(1-6C hydrocarbon)substituted silyl] in the presence of palladium catalyst.
|
