| 摘要 |
The present invention relates to certain novel piperidyl amides, sulfonamides an d sulfoxamides of formula (I) and (II) which are useful as inhibitors of cholesterol biosynthesis and as agents which l ower total serum cholesterol in patients in need thereof, wherein A is a C2-C14 alkylene; Y is a methylene, oxygen, sulfur, sulfi nyl or sulfonyl; B is a C2-C14 alkylene, (a) or (b); m is an integer 0 or l; v is an integer 0, 1 or 2; and R is -(CH2)mOH, with the proviso that when m is 0, R cannot be in the 2-position of the piperidine ring or a radical of formula (c), wherein n is an integer 0, 1, 2, or 3; and Rl is hydrogen, phenyl, vinyl or a C1-C4 alkyl; provided that when R is a radical of formula (c) , Y is not methylene.
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