Modulators of beta-amyloid peptide aggregation

摘要

Compounds that act to modulate the aggregation of natural beta amyloid peptides ( beta -AP) are disclosed. The beta amyloid modulators of the invention can promote beta -AP aggregation or, more preferably, can inhibit natural beta -AP aggregation. Furthermore, the modulators are capable of altering natural beta -AP aggregation when the natural beta -APs are in a molar excess amount relative to the modulators. Preferred beta amyloid modulators comprise amino-terminally biotinylated beta amyloid peptide compounds. Pharmaceutical compositions comprising the compounds of the invention, and methods of altering natural beta -AP aggregation using the compounds of the invention, are also disclosed.