Naphthyridine derivatives and pharmaceutical compositions thereof

摘要

PCT No. PCT/JP95/01700 Sec. 371 Date Jan. 30, 1997 Sec. 102(e) Date Jan. 30, 1997 PCT Filed Aug. 28, 1995 PCT Pub. No. WO96/06843 PCT Pub. Date Mar. 7, 19961,8-Naphthyridine derivatives represented by the following general formula (I), salts thereof, hydrates thereof and solvates thereof. <IMAGE>osphodiesterase and are useful as agents for the prevention and treatment of respiratory diseases, inflammatory diseases accompanying organ transplantation, systemic or local arthropathy, proliferative diseases, micturition-related diseases and diseases in which tumor necrosis factor (TNF) and other cytokine (IL-1, IL-6 or the like) are concerned.