| 发明名称 |
Inhibitors of farnesyl-protein transferase |
| 摘要 |
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
|
| 申请公布号 |
US5817678(A) |
申请公布日期 |
1998.10.06 |
| 申请号 |
US19960749254 |
申请日期 |
1996.11.15 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
KIM, BYEONG M.;SHAW, ANTHONY W.;GRAHAM, SAMUEL L.;DESOLMS, S. JANE;CICCARONE, TERRENCE M. |
| 分类号 |
C07D233/24;C07D401/12;(IPC1-7):A61K31/445 |
主分类号 |
C07D233/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
