摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing a methylated derivative ofγ- cyclodextrin in a high yield. SOLUTION: This method for producing a methylatedγ-cyclodextrin comprises protecting hydroxyl group at 2 position of (6-O-tert- butyldimethylsilyl)-γ-cyclodextrin with a protecting group, de-silylating, then methylating the hydroxyl groups at 3 and 6 positions and then removing the protecting group, or protecting the hydroxyl group at the 2 position of (6-O-tert- butyldimethylsily)-γ-cyclodextrin with a protecting group, methylating the hydroxyl group at the 3 position, de-silylating, and then removing the protecting group, or protecting the hydroxyl group at the 2 and 6 positions of cyclodextrin with a protecting group selected from allyl, benzyl and p-methoxybenzyl group, methylating the hydroxyl group at the 3 position, then removing the protecting group a the 2 and 6 positions. Also, as a catalyst for protecting the hydroxyl groups with the protecting group, a mixed base consisting of barium oxide and barium hydroxide octahydrate is used.
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