发明名称 |
Reshaped human antibody to human interleukin-6 receptor |
摘要 |
A reshaped human antibody to the human IL-6R, comprising: (A) an L chain comprising, (1) a human L chain C region, and (2) an L chain V region comprising human L chain framework regions (FRs), and mouse L chain complementary determination regions (CDRs) of a monoclonal antibody to the IL-6 receptor (IL-6R); and (B) an H chain comprising, (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRs, and mouse H chain CDRs of a monoclonal antibody to the IL-6R. Since major portion of the reshaped human antibody is derived from a human antibody and the mouse CDRs which are less immunogenic, the present reshaped human antibody is less immunogenic to human, and therefor is promised for therapeutic uses.
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申请公布号 |
US5817790(A) |
申请公布日期 |
1998.10.06 |
申请号 |
US19950436717 |
申请日期 |
1995.05.08 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI |
发明人 |
TSUCHIYA, MASAYUKI;SATO, KOH;BENDIG, MARY MARGARET;JONES, STEVEN TARRAN;SALDANHA, JOSE WILLIAM |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61P35/00;C07K16/18;C07K16/24;C07K16/26;C07K16/28;C07K19/00;C12N5/10;C12N15/13;C12P21/08;C12R1/91;G01N33/53;G01N33/577;(IPC1-7):C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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