| 摘要 |
The present invention provides a unique eukaryotic gene, called LAG1, which controls the longevity of eukaryotic cells. According to the present invention, overexpression of LAG1 in older cells has a rejuvenating effect which not only increases cellular life span but also reproductive capacity and cellular tolerance to stress factors such as starvation and low pH. Moreover, the present invention identifies two domains in LAG1 one having a life span limiting function and the other a life span extending function. Hence, according to the present invention, the longevity and tolerance to stress of cells is increased when provided with the wild type polypeptide or mutant LAG1 polypeptides which, for example, lack the "life span limiting domain.
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