发明名称 |
Permeation enhancer compositions for increased absorption of therapeutic proteins through the colonic membrane |
摘要 |
The present invention is directed to a pharmaceutical formulation of a therapeutic polypeptide together with a permeation-enhancing mixture of sodium 3-nitrobenzoate and an oil to provide enhanced absorption of the polypeptide through the wall of the gastrointestinal tract, and particularly of the colon, after oral administration.
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申请公布号 |
US5817624(A) |
申请公布日期 |
1998.10.06 |
申请号 |
US19950465661 |
申请日期 |
1995.06.05 |
申请人 |
ALZA CORPORATION |
发明人 |
YANG, HEECHUNG;MYRBACK, ROBERT E.;FOX, DEBORAH A.;NGUYEN, VU ANH |
分类号 |
A61K9/48;A61K38/27;A61K38/28;A61K47/12;A61K47/44;(IPC1-7):A61K38/27;A61K31/04 |
主分类号 |
A61K9/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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