| 摘要 |
<p>There are disclosed 2-amino-alkanoic and alkenoic acid derivatives, amino alcohols and diamines represented by the general formula (I), (II), (III) respectively and the corresponding products resulting from the hydrogenation of the double bond(s), wherein R<SP>1</SP>, R<SP>2</SP> = H, amino protective groups such as benzyl, tert-butoxycarbonyl, benzyloxycarbonyl, fluorenylmethoxycarbonyl; wherein R<SP>3</SP> = aromatic, heterocyclic, carbocyclic, linear or branched saturated chain, alkyl carbonyl, alkoxy carbonyl and nitrile; wherein R<SP>4</SP> = H, alkyl; wherein R<SP>5</SP> = H, OH, alkyl, alkoxy, NH 2 , N-alkyl, or acyl groups; wherein m # 1; n # 0; o # 1; p # 0; q # 0; their geometrical isomers, their enantiomeric forms, their pharmacologically and immunologically acceptable salts and their uses. An amino-protected form of methyl 2-amino-eicos-5(z)-enoate was prepared and reduced to the corresponding alcohol and converted to the diamine. The compounds of formula I, II and III are stated to have pharmacological activity for a wide and diverse range of conditions.</p> |
