发明名称 |
Production and use of multimeric hemoglobins |
摘要 |
Multimeric hemoglobin-like proteins are obtained by crosslinking cysteines, natural or artificial, of the component tetramers, or by genetically fusing globin-like domains of one tetramer with those of another, by means of an interdomain spacer sequence. Artificial cysteines are introduced selectively in a single globin-like domain per tetramer to control polymerization. <IMAGE> |
申请公布号 |
EP0857489(A3) |
申请公布日期 |
1998.09.30 |
申请号 |
EP19970203723 |
申请日期 |
1992.11.06 |
申请人 |
SOMATOGEN, INC. |
发明人 |
ANDERSON, DAVID C.;MATHEWS, ANTHONY J.;STETLER, GARY L. |
分类号 |
A61K38/16;A61K38/00;A61K47/48;A61P7/08;C07K;C07K1/113;C07K14/805;C12N15/00;C12N15/09;C12N15/12;C12N15/81;C12P21/02;C12R1/19;C12R1/91 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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