| 摘要 |
Cyclic sulphones of formula (I) are disclosed, in which: R1 and R2 each independently of one another stand for H, A, CF3, CH2F, CHF2, C2F5, Hal, OH, OA, NH2, NHA, NA2, NO2 or CN; X stands for CR4R5, C=Z, O, S, NH, NA or NR3; Y stands for CR6R7, C=Z, O, NH, NA, or NR3; Z stands for O, S, NH, NA, NOH, NOA, CH2, CHA or CA2; R4, R5, R6 and R7 each independently of one another stand for H, A, R3, Hal, OH, OA, SH, SA, NH2, NHA or NA2, or alternatively, R5 and R6 or R7 and R8 can together represent a bond, only one such bond being present in each molecule; R4 and R5 together can also stand for O-(CH2)2-O or O-(CH2)3-O; R8 and R9 each independently of one another stand for H or A; A stands for alkyl with 1-6 C atoms; Hal stands for F, Cl, Br or I; and R3 stands for phenyl or benzyl which is unsubstituted or single-, double- or triple-substituted by A, OA, NH2, NHA, NA2, F, Cl, Br and/or CF3; and n is 0 or 1. Also disclosed are the physiologically tolerable salts of these compounds. These compounds and their salts have anti-arrhythmic properties and act as inhibitors of the cellular Na+/H+-antiporter.
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