Expression of macrophage inducible proteins (MIPS) in yeast cells

摘要

Methods for the expression of mammalian MIP-1 alpha and MIP-1 beta are disclosed. The methods generally comprise introducing into a yeast cell, a DNA molecule capable of directing the expression and if desired the secretion of either MIP-1 alpha or MIP-1 beta . Methods for expression of constructs encoding both MIP-1 alpha and MIP-1 beta are also described. The MIP molecules so produced are biologically active.