| 摘要 |
The present invention is directed to a process for the production of biotin from desthiobiotin which comprises contacting desthiobiotin with an enzyme reaction system containing BIOB and also NIFU and/or NIFS, and isolating the resulting biotin from the reaction mixture and to a process for the production of biotin from desthiobiotin which comprises cultivating a microorganism, which has been transformed by the DNA sequences itself encoding BIOB and NIFU and/or NIFS or such DNA sequences comprised by a single or independent from each other by several plasmids, in an aqueous nutrient medium, in the presence of desthiobiotin, and isolating the resulting biotin from the culture medium. |
