发明名称 |
Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers |
摘要 |
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.
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申请公布号 |
US5814667(A) |
申请公布日期 |
1998.09.29 |
申请号 |
US19970814419 |
申请日期 |
1997.03.11 |
申请人 |
UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
MITCHELL, JAMES B.;RUSSO, ANGELO;KRISHNA, MURALI C.;WINK, JR., DAVID A.;LIEBMANN, JAMES E. |
分类号 |
A61K31/13;A61K31/131;A61K31/14;A61K31/15;A61K31/44;A61K31/445;A61K31/495;A61K31/787;A61K38/06;A61K38/17;A61K41/00;A61K45/06;(IPC1-7):A61K31/13 |
主分类号 |
A61K31/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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