| 摘要 |
PROBLEM TO BE SOLVED: To provide a new protein useful for research and a therapeutic agent, etc., of nerval denaturation disease such as Parkinson disease or Alzheimer disease, having a specific amino acid sequence and comprising a protein HUCEP-1 exhibiting activity for activating nerve cell function. SOLUTION: This new protein is an HUCEP-1 comprising an amino acid sequence of the formula and having an activity for activating nerve cell function, or a protein comprising an amino acid sequence in which one or several amino acids are deleted, substituted or added in an amino acid sequence of the formula and having an activity for activating nerve cell function, and is useful as a research reagent for cause elucidation or a therapeutic agent, etc., of nerval denaturation disease such as Parkinson disease or Alzheimer disease. The protein is obtained by cloning the HUCEP-1 gene from a cDNA library prepared based on mDNA separated from a human cerebral cortex, integrating the resultant gene into a manifestation vector and manifesting itself in a host cell. |
