发明名称 |
METHOD OF PREPARING .ALPHA.-L-ASPARTYL-L-PHENYLALALINE METHYL ESTER HYDROCHLORIDE |
摘要 |
.alpha.-L-Aspartyl-L-phenylalanine methyl ester hydrochloride is prepared by extracting N-formyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester from a reaction mixture containing same in an organic solvent, with water at a temperature of from 40.degree.C to 80.degree.C, and allowing the resulting mixture to separate into an aqueous layer and an organic layer, the aqueous layer containing the N-formyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester. The aqueous layer is isolated and the N-formyl-a-L-aspartyl-L-phenylalanine methyl ester contained therein is deformylated at a temperature of from 40.degree.C to 80.degree.C. .alpha.-L-Aspartyl-L-phenylalanine methyl ester is thereafter crystallized out in the form of its hydro-chloride salt. The method of the invention does not necessitate the isolation of an intermediate by solid-liquid separation during the course of preparing the .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride.
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申请公布号 |
CA2069352(C) |
申请公布日期 |
1998.09.29 |
申请号 |
CA19922069352 |
申请日期 |
1992.05.25 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
KATO, TOSHIHISA;KISHIMOTO, SHINICHI;TAKEDA, HIDEO;KANO, MIKIYA;TAKEMOTO, TADASHI |
分类号 |
C07K1/02;C07K1/14;C07K5/075;(IPC1-7):C07K5/075 |
主分类号 |
C07K1/02 |
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