| 摘要 |
PROBLEM TO BE SOLVED: To obtain a composition capable of treating peripheral neuropathy of diabetes, vascular deformation or diabetic retinal damage by including a spin trapping compound, etc. SOLUTION: This composition contains a compound of formula I (X is phenyl, etc.; Y is t-butyl capable of being hydroxylated or acetylated, phenyl, etc.), formula II (A, B are each CH3 , CH2 OH, etc.), or formula III (S is H, etc.), as an active ingredient. The ingredient is contained together with a pharmaceutically acceptable carrier for administering the ingredient into a patient, and is combined with particles, liposome, an immobilizing substance, a polymeric support, a buffering agent, etc., to prepare the composition. The administration does of the active ingredient is 1-300mg ofα-phenyl-t-butylnitron per kg of a body weight. The composition is effective for treating apoplexy, functional disorders related to ages and other diseases caused by oxidative damages.
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