PROCESS FOR PREPARATION OF UNSUBSTITUTED PROPAGYLIC ALCOHOLS AND USE OF ORGANOBORON COMPOUNDS FOR THE PREPARATION

摘要

The novel organoboron reagent of the present invention is useful in the preparation of unsubstituted propargylic alcohols. This compound reacts with aldehydes and ketones cleanly to afford propargylic alcohols in excellent yields. Unsubstituted propargylic alcohols are important synthetic intermediates in the synthesis of a number of natural products. In addition, the novel organoboron reagent of the present invention also demonstrates diastereomeric selectivity when reacted with enatiomerically pure aldehydes.