Nucleic acid molecule that comprises an incomplete fused hepatitis C and hepatitis B viral genome or an incomplete hepatitis C viral genome including specifically disclosed DNA sequences are disclosed. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C and hepatitis B viral genome including a nucleotide sequence encoding a complete hepatitis C core protein and hepatitis B S gene protein or an incomplet hepatitis C viral genome including a nucleotide sequence encoding a complete hepatitis C core protein, operably linked to regulatory elements functional in human cells are disclosed. Methods of immunizing individuals susceptible to or infected by hepatitis B virus and/or hepatitis C virus comprising the step of administering such pharmaceutical compositions are disclosed.
申请公布号
HUT77870(A)
申请公布日期
1998.09.28
申请号
HU19980001385
申请日期
1995.10.05
申请人
APOLLON,INC.;THE GENERAL HOSPITAL CORPORATION
发明人
CONEY,LESLIE R.;PACHUK,CATHERINE J.;TOKUSHIGE,KATSUTOSHI;WAKITA,TAKAJI;WANDS,JACK;ZURAWSKI,VINCENT R.