摘要 |
FIELD: organic synthesis. SUBSTANCE: invention relates to high-efficiency angiotensin II receptor antagonists and provides compounds with general formula I: <EMI ID=0.25 HE=27 WI=42 TI=CHI> where R<SB>2B</SB> and R<SB>3B</SB>, the same or different, are hydrogen, lower alkyl, lower fluoroalkyl, and lower thioalkyl; A<SB>1B</SB>, A<SB>2B</SB>, A<SB>3B</SB> and A<SB>4B</SB> are carbon or nitrogen, one or two of them being nitrogen and at least one of them being methyne group; R<SB>3</SB> is hydrogen, hydroxyl, alkyl, hydroxyalkyl, phenyl, alkoxycarbonyl, and thioalkyl; R<SB>4</SB> hydrogen, hydroxyl, arylalkyl, arylalkoxy, aryloxy, and arylamino groups. Compound I is prepared by reaction of compound II (formula <EMI ID=0.26 HE=24 WI=24 TI=CHI>) with compound <EMI ID=0.27 HE=6 WI=45 TI=CHI> where <EMI ID=0.28 HE=6 WI=21 TI=CHI> are the same as R<SB>2B</SB> and R<SB>3B</SB> in compound I, <EMI ID=0.29 HE=6 WI=21 TI=CHI> are R<SB>4</SB> in which reactive groups can be protected, and alk is C<SB>1</SB>-C<SB>6</SB>-alkyl, to form compound III (formula <EMI ID=0.30 HE=30 WI=33 TI=CHI>) that is further subjected to cyclization. Reaction is carried out in organic solvent. EFFECT: new efficient drugs prepared. 7 cl, 38 ex
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