DERIVATIVES OF 2-DEOXY-2,3-DIDEHYDRO-N-ACETYLNEURAMINIC ACID, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT

摘要

FIELD: organic chemistry. SUBSTANCE: invention proposes derivatives of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid of the formula (I) where R is azide or group -NR6bR being R is hydrogen, C1-6--alkyl or allyl; R is NHCOR where R is C1-6-alkyl, or their pharmaceutically acceptable salts and ester salts. Method of synthesis of compounds of the formula (I) involves interaction of derivative of the formula (III) protected by carboxy- and hydroxy-groups where R has above indicated value; OL - group to be removed with nucleophilic group followed by conversion to amine, guanidine, salt, ester of ester salt. Invention proposes also pharmaceutical composition showing antiviral activity with respect to ortho-paramyxoviruses that contains a compound of the formula (I) as an active component taken at effective amount. Invention proposes also a method of treatment of mammals including human with viral infections by administration of compounds of the formula (I) at the dose 0.01-750 mg/kg body mass/day in respiratory ways or by intranasal route. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 15 cl, 15 dwg, 3 tbl, 24 ex