4:substituted quinolin:2:one derivatives used as serotonin antagonists

摘要

Novel quinolin-2-(1H)-one derivatives of formula (I) and their salts with acids and bases, are claimed, where R1, R2 = H, halogen, amino, OH, NO2, CN, 1-6C alkyl or alkoxy, CF3, CF3O, -COOH, -COOR5, -CONH2, -CONHR5, -CONHR5R6, -SR5, -SO2R5, -NHCOR5, -NHSO2R5, or -N(R5)2, R3 = H, 1-4C alkyl, -(CH2)p-OH, -(CH2)pNH2, -(CH2)nCN, -(CH2)n tetrazol- 5-yl, -(CH2)n COOH, -(CH2)nCOOR5, -(CH2)nCONH2, (CH2)n, -CONHOH, -(CH2)pSH, -(CH2)nSO3H, -(CH2)nSO2NH2, -(CH2)nSO2NHR5, -(CH2)nSO2NR5R6, -(CH2)nCONHR5, -(CH2)nCONR5R6, -(CH2)pNHSO2R5, -(CH2)pNHCOR5, -(CH2)pOCOR5; R5, R6 = 1-4C alkyl; m = 2, 3 or 4; n = 1, 2, 3 or 4; and p = 2, 3, or 4.