PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVES

摘要

A process for producing quinazoline derivatives of general formula (I) or salts thereof on an industrial scale, wherein R<1> represents hydrogen or halogen; R<2> represents carboxyl or protected carboxyl; and A represents lower alkylene, by reacting a compound of the general formula (II): C1-A-R<2>, wherein R<1> is as defined above, or a salt thereof with a silylating agent and then with a compound of general formula (III), wherein R<1> and A are each as defined above, or a salt thereof and, if necessary, desilylating the product.